Benfotiamine is also more bioavailable than the water-soluble thiamine.¹ In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways. Benfotiamine also blocked the activation of the transcription factor known as nuclear factor-kappa B (NF-kB). ²

Overall, benfotiamine can modulate glucose metabolism and promote healthy blood glucose levels already within the normal range. By doing so, benfotiamine also helps inhibit the formation of AGEs and supports healthy endothelial function.³